RZQ-12K Dissolution Sampling and Collection System

Main Features

● Equipped with 14 dissolution vessels, 12 basket rods, and 12 paddle rods, which can meet the requirements of the control test with blank and standard products.

● The machine head is electrically raised and lowered, with a high degree of automation.

● Two dissolution test methods, paddle method and basket method, are standard, and five pharmacopeia dissolution test methods including small cup method, plate method (large plate and small plate), and rotating cylinder method (long cylinder and short cylinder) are optional.

● The automatic height-fixing clutch is adopted, and there is no need to manually fix the height of the rotating rod. Different test methods are applicable, and there is no need to repeat the height setting after changing different test devices. 5. With automatic dosing function, it can realize simultaneous dosing and sequential dosing.

● Granules can be administered.

● The sampling rack automatically rises and falls, and the sampling point is automatically determined.

● 12 channels of solvent temperature monitoring can be set to real-time monitoring or sampling monitoring according to user habits.

● Solvent lighting (including light-avoiding drug red lighting).

● Built-in WiFi module. 11. Can run online with the sampler.

● The bottom surface of the machine head is designed with a tapered sealing cup cover, so that the solvent evaporated droplets fall back into the dissolution cup to avoid solvent evaporation pollution.

● It adopts automatic centering cup holder and cup holder ring, and is equipped with high-precision dissolution vessel. Realize the automatic centering of the rotating rod and the dissolution vessel without manual adjustment. 14. The water bath box and the circulation pipeline are connected by quick joints, and there is an independent water outlet, which is easy to disassemble and clean. 15. Using LCD touch screen, the operation interface is intuitive and easy to use.
● With user management function, you can log in to the user account through the user name and password and fingerprints, and have a guest account. After activation, any user can log in to the account. After logging in, you can set various parameters and run tests under this account.

● The speed of the dissolution apparatus is regulated in different zones, and the section can simultaneously conduct comparative experiments of different speeds.

Main Features of Sampler

● High resolution color touch screen

● Built-in printer

● Fingerprint recognition

● Using precision glass syringe as sampling power

● Adopt 12-channel high precision, high chemical stability valve body

● High chemical stability PTFE pipeline has excellent anti-adsorption function

● Pre-test filter infiltration technology to reduce adsorption

● The liquid return circulation technology of the sampler and the pipeline emptying technology after sampling avoid cross-contamination

● Has the function of isothermal rehydration

● With the function of distribution and dilution

● It has 12 independent pipeline systems, which can meet the control requirements of the dissolution test for blank and standard products

● Sampling double-stage filtration, the primary filtration is a columnar filter head with a 10μm pore size, and the secondary filtration can be selected without filtering or a 0.8μm/0.45μm/0.22μm pore size φ25mm syringe filter as required

● 15-place test tube rack, can hold up to 180 test tubes

● The sampling tube is equipped with a silicone cap to prevent evaporation and contamination of the sample

● Using color touch screen, Chinese menu prompts, the instrument is easy to operate

● Can run online with dissolution apparatus

● Ampoule collection device (optional)

Technical Indicators

● Swing amplitude of stirring paddle: ≤0.5mm

● Swing amplitude of rotating basket: ≤1.0mm

● Deviation between the rotating rod and the dissolution cup axis: ≤1.0 mm

● Speed regulation range: 10－300 rev/min

● Speed resolution: 0.1 rev/min

● Steady speed error:≤±1rev/min

● Temperature regulation range: Room temperature－45.0℃

● Temperature resolution: 0.01℃

● Temperature control error: ≤±0.3 ℃

● 14-cup solvent temperature monitoring resolution: 0.01℃

● Charging interval：10－300 seconds

● Sampling point resolution: 1ml

● Basic test timing: ≤999h59min

● Program-controlled test procedure: 99 groups x 7 users

● Program-controlled sampling times: 15 times, meeting the national requirements on quality consistency evaluation of genetic drugs.

● Program-controlled sampling time: ≤999h 59min

● Working noise: ＜60 dB（A）

● Working environment: environment temperature:（5－35）℃, relative humidity:≤80％

● Safety performance: In line with national industry standards

● Power requirements: AC 220V 50Hz 10A

● Dissolution tester speed regulation according to areas, contract tests at different speeds can be performed at the same time.

Technical Indicators of Sampler

● Number of sampling channels: 12

● Maximum times of sampling: 15

● Maximum times of distribution: 15

● Maximum sampling interval: 99h59min

● Minimum sampling interval: 1 minute for the first time, 3-10 minutes for the remaining (depending on the sampling volume and whether fluid replenishing and distribution are performed)

● Continuous working time: 99h59min×15

● Sampling filter period: ＜30 seconds

● Sampling volume (or fluid replenishing volume): 1ml~100ml

● Single tube distribution volume:1ml~15ml

● Single tube dilution volume: 1ml~15ml

● Sampling precision: RSD1% (average of each channel when the sampling volume is 10ml)